Adstiladrin Bladder Cancer Treatment

Adstiladrin (nadofaragene firadenovec-vncg) is a medicine used to treat adults with a type of bladder cancer called high-risk non-muscle invasive bladder cancer (NMIBC) that has not responded to a treatment called BCG. It is for patients who have carcinoma in situ (CIS), with or without small growths called papillary tumors.

How does Adstiladrin work?

Adstiladrin is a gene therapy. It uses a harmless virus to deliver a gene into the cells lining your bladder. This gene helps your body make a protein called interferon alfa-2b, which can help fight cancer cells.

How is Adstiladrin given?

Adstiladrin is put directly into your bladder through a thin tube called a catheter. You will get this treatment once every three months. The medicine stays in your bladder for one hour before you empty it. You may be given a medicine called an anticholinergic before treatment to help with bladder spasms.

What are the possible side effects?

Most side effects are mild and go away on their own. Common side effects include:

• Discharge from where the medicine was put in
• Feeling tired
• Bladder spasms
• Needing to urinate urgently
• Blood in the urine
• Pain or burning when urinating
• Fever or chills
• Changes in blood tests, like higher blood sugar or triglycerides

Serious side effects are rare, but let your healthcare provider know if you feel very unwell or have new symptoms. Some people may need to stop treatment if side effects are severe.

Important safety information:

• If you have a weak immune system or take medicines that lower your immunity, you should not come into contact with Adstiladrin, as there is a small risk of infection from the virus used in the medicine.
• For two days after treatment, you should disinfect your urine with bleach before flushing, as the medicine can be present in your urine for a short time.
• Delaying surgery to remove the bladder (cystectomy) in some patients may increase the risk of the cancer spreading. Talk to your doctor about the risks and benefits of all treatment options.

What should I do after treatment?

Follow your healthcare provider’s instructions for care after treatment. Let them know if you have any side effects or concerns. You will have regular check-ups to see how well the treatment is working.[1]

If you have questions about Adstiladrin or your bladder cancer treatment, ask your healthcare team. They are there to help you understand your options and support you.

References
ADSTILADRIN. Food and Drug Administration. Updated date: 2025-10-10.

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